Research Articles
Decoding AISI: A Biomarker's Critical Role in Predicting Hospital Length of Stay and Resource Allocation
This article provides a comprehensive analysis of the Aggregate Index of Systemic Inflammation (AISI) and its significant correlation with hospital length of stay (LOS).
Comparing AISI, SII, and SIRI in Abscess Prognosis: A Performance Analysis for Biomarker Selection
This article provides a comprehensive, evidence-based analysis of three systemic inflammatory indices—the Aggregate Index of Systemic Inflammation (AISI), Systemic Immune-Inflammation Index (SII), and Systemic Inflammation Response Index (SIRI)—in the context...
Biomarker Battle: Analyzing AISI vs. Traditional Inflammatory Biomarkers for Superior Disease Monitoring and Prognosis
This article provides a comprehensive, evidence-based analysis for researchers, scientists, and drug development professionals on the Area under the Curve (AUC) comparison of the Aggregate Index of Systemic Inflammation (AISI)...
Decoding Astrocyte Polarization: A1 vs. A2 Phenotypes in Neuroprotection, Neurotoxicity, and Therapeutic Targeting
This comprehensive review synthesizes current knowledge on the polarization of astrocytes into neurotoxic A1 and neuroprotective A2 states, a critical axis in central nervous system health and disease.
How ROS Oxidizes DNA: The Complete Guide to 8-OHdG Formation, Measurement, and Clinical Significance
This article provides a comprehensive, up-to-date analysis of the molecular mechanisms by which reactive oxygen species (ROS) generate the quintessential oxidative DNA lesion, 8-hydroxy-2'-deoxyguanosine (8-OHdG).
8-OHdG and OGG1: The Crucial Oxidative DNA Repair Pathway in Disease and Drug Discovery
This comprehensive review examines the 8-hydroxy-2'-deoxyguanosine (8-OHdG) base excision repair pathway, primarily mediated by the OGG1 glycosylase.
8-OHdG in Cancer: Decoding Its Dual Role as a Diagnostic Biomarker and Prognostic Indicator
This article provides a comprehensive analysis of 8-hydroxy-2'-deoxyguanosine (8-OHdG) in oncology, addressing its distinct yet interconnected roles in cancer detection and outcome prediction.
8-OHdG as a Biomarker of Chronic Oxidative Stress: A Comprehensive Guide for Research and Drug Development
This article provides a comprehensive overview of 8-hydroxy-2'-deoxyguanosine (8-OHdG) as a key biomarker for chronic oxidative stress.
Decoding 4-HNE and 4-HHE in Microglia: Mechanisms, Methods, and Therapeutic Implications in Neuroinflammation
This article provides a comprehensive analysis of 4-hydroxynonenal (4-HNE) and 4-hydroxyhexenal (4-HHE), two key bioactive lipid peroxidation products, in the context of microglial cell biology and neuroinflammation.
Beyond the Petri Dish: Leveraging 3D Cell Culture Models for Advanced NF-κB Pathway Suppression Studies in Drug Discovery
This article provides a comprehensive guide for researchers and drug development professionals on utilizing advanced 3D cell culture models to study NF-κB pathway suppression.