Research Articles
8-OHdG as a Biomarker of Chronic Oxidative Stress: A Comprehensive Guide for Research and Drug Development
This article provides a comprehensive overview of 8-hydroxy-2'-deoxyguanosine (8-OHdG) as a key biomarker for chronic oxidative stress.
Decoding 4-HNE and 4-HHE in Microglia: Mechanisms, Methods, and Therapeutic Implications in Neuroinflammation
This article provides a comprehensive analysis of 4-hydroxynonenal (4-HNE) and 4-hydroxyhexenal (4-HHE), two key bioactive lipid peroxidation products, in the context of microglial cell biology and neuroinflammation.
Beyond the Petri Dish: Leveraging 3D Cell Culture Models for Advanced NF-κB Pathway Suppression Studies in Drug Discovery
This article provides a comprehensive guide for researchers and drug development professionals on utilizing advanced 3D cell culture models to study NF-κB pathway suppression.
Designing a Robust 10-Color Flow Cytometry Panel for Macrophage Polarization: A Comprehensive Guide for Immunology Researchers
This guide provides a detailed framework for designing, validating, and applying a 10-color flow cytometry panel to comprehensively analyze macrophage polarization states (M1, M2, and beyond).
Neuroinflammation in Neurodegeneration: Mechanisms, Biomarkers, and Therapeutic Strategies
This article provides a comprehensive analysis of the pivotal role inflammatory responses play in the pathogenesis of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and Amyotrophic Lateral Sclerosis.
Mouse Peritonitis Models: A Comprehensive Guide for Evaluating Inflammatory Responses in Preclinical Research
This article provides a systematic overview of mouse peritonitis models, essential tools for studying inflammatory responses, sepsis, and evaluating novel therapeutics.
Systemic Inflammation Biomarkers in Disease Prognostication: A Comprehensive Analysis of NLR, PLR, and LMR Across Clinical Contexts
This comprehensive review synthesizes current evidence on neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR) as prognostic biomarkers across inflammatory diseases and cancer immunotherapy.
Comprehensive Flow Cytometry Guide for Macrophage M1/M2 Polarization Analysis
This article provides a complete framework for analyzing macrophage M1/M2 polarization using flow cytometry, tailored for researchers and drug development professionals.
Cytokine Detection Sensitivity: A Comprehensive Comparison of Methods for Biomarker Research and Drug Development
Accurate cytokine quantification is crucial for understanding immune responses, disease mechanisms, and therapeutic efficacy in biomedical research and drug development.
Transcription Factors as Inflammatory Markers: A Comparative Analysis of NF-κB, STAT, and IRF in Disease and Drug Development
This article provides a comprehensive comparative analysis of key inflammatory transcription factors—NF-κB, STAT, and IRF—as biomarkers in biomedical research and therapeutic development.