Research Articles
Resolving Identifiability Issues in Mathematical Models of Inflammation: A Guide for Robust Quantification
Mathematical modeling is crucial for understanding the complex dynamics of inflammatory responses and developing effective therapeutics.
Standardizing Macrophage Polarization: From Foundational Concepts to Reproducible Protocols Across Models
This article provides a comprehensive framework for standardizing macrophage polarization protocols, addressing a critical need in biomedical research.
Overcoming Analytical Validation Limitations: A Strategic Framework for Clinical Researchers and Drug Developers
This article provides a comprehensive framework for researchers, scientists, and drug development professionals to navigate the complex challenges of analytical validation in clinical practice.
Optimizing Inflammatory Marker Stability: A Comprehensive Guide to Storage Conditions for Reliable Research and Diagnostics
This article provides a definitive guide for researchers and drug development professionals on optimizing storage conditions to ensure the stability of inflammatory markers.
Navigating the Technical Challenges in 8-OHdG Measurement: A Guide for Accurate Biomarker Analysis
Accurate quantification of 8-hydroxy-2'-deoxyguanosine (8-OHdG) is critical for its reliable use as a biomarker of oxidative stress in research and clinical applications.
Beyond Discovery: A Strategic Framework for Robust Clinical Validation of Novel Inflammatory Biomarkers
This article provides a comprehensive roadmap for researchers, scientists, and drug development professionals aiming to navigate the complex journey of clinically validating novel inflammatory biomarkers.
Preserving Cytokine Integrity: A Scientific Guide to Preventing Degradation During Freeze-Thaw Cycling
Accurate cytokine quantification is critical for biomedical research and clinical trials, yet pre-analytical variables like freeze-thaw cycling and storage conditions can significantly compromise data integrity.
Neutrophil Apoptosis Assays: A Comprehensive Guide for Assessing Inflammation Resolution in Research and Drug Development
This article provides a comprehensive guide for researchers and drug development professionals on the critical role of neutrophil apoptosis assays in evaluating inflammation resolution.
Ex Vivo Lipoprotein Oxidation Stability: Methods, Validation, and Clinical Applications in Cardiovascular Research
This article provides a comprehensive resource for researchers and drug development professionals on the ex vivo measurement of lipoprotein oxidation stability, a key process in atherogenesis.
Nuclear Fraction Isolation for NF-κB Translocation Assays: A Comprehensive Guide from Basics to Advanced Applications
This article provides researchers, scientists, and drug development professionals with a comprehensive guide to nuclear fraction isolation techniques specifically optimized for NF-κB translocation assays.