Research Articles
Decoding Innate Immunity: A Comparative Transcriptomics Guide to Macrophage PAMP Response Patterns
This comprehensive article provides researchers, scientists, and drug development professionals with a detailed exploration of comparative transcriptomics in macrophage responses to Pathogen-Associated Molecular Patterns (PAMPs).
Bacterial vs. Fungal PAMPs: A Comparative Analysis of Immunostimulatory Efficacy for Therapeutic Applications
This article provides a comprehensive comparative analysis of the efficacy of Pathogen-Associated Molecular Patterns (PAMPs) derived from bacteria versus fungi in stimulating innate immune responses.
ChIP-seq Master Guide: In Vivo Transcription Factor Binding Profiling for Research & Drug Discovery
This comprehensive guide provides researchers, scientists, and drug development professionals with a detailed roadmap for Chromatin Immunoprecipitation followed by sequencing (ChIP-seq) to profile in vivo transcription factor (TF) binding.
Decoding Neuroinflammation: A Comprehensive Guide to CSF Biomarkers sTREM2 and GFAP for Research and Drug Development
This article provides a detailed exploration of cerebrospinal fluid (CSF) biomarkers sTREM2 (soluble Triggering Receptor Expressed on Myeloid cells 2) and GFAP (Glial Fibrillary Acidic Protein) for assessing neuroinflammation.
Unlocking Macrophage Biology: A CRISPR Screening Guide to NF-κB Pathway Regulators for Immunology Research
This comprehensive guide details the application of CRISPR screening to identify and validate regulators of the NF-κB pathway in macrophages, a critical nexus in inflammation, immunity, and disease.
Decoding Macrophage Polarization: A Flow Cytometry Guide to M1/M2 Markers CD64, CD40 & CD200R
This comprehensive guide provides researchers, scientists, and drug development professionals with a detailed protocol and critical analysis for characterizing macrophage polarization states (M1 and M2) using flow cytometry.
Beyond M1/M2: CD38/Egr2 Flow Cytometry Reveals New Macrophage Polarization Paradigms for Immunotherapy
This article provides a comprehensive guide for researchers comparing novel (CD38, Egr2) and classical (iNOS, Arg1, CD206) macrophage polarization markers in flow cytometry.
CRP in GLIM Diagnosis: The Critical Role of Inflammation in Identifying and Managing Malnutrition
This article provides a comprehensive analysis for researchers, scientists, and drug development professionals on the integration of C-reactive protein (CRP) within the Global Leadership Initiative on Malnutrition (GLIM) diagnostic framework.
BMDM Training with PAMPs: A Comprehensive Protocol for Innate Immune Memory Research and Drug Discovery
This article provides a complete guide for researchers on the principles and practical execution of Bone Marrow-Derived Macrophage (BMDM) training using Pathogen-Associated Molecular Patterns (PAMPs).
Mastering the Lifespan: Bcl-2 Family Proteins as Central Regulators of Neutrophil Apoptosis in Health and Disease
This comprehensive review explores the pivotal role of Bcl-2 family proteins in regulating neutrophil apoptosis, a critical determinant of inflammation resolution and immune homeostasis.