Research Articles
The Oxidative-Inflammatory Axis in Chronic Disease: Mechanisms, Biomarkers, and Emerging Therapeutic Strategies
Chronic diseases, including cardiovascular, metabolic, and neurodegenerative disorders, share a common pathological denominator: a self-perpetuating cycle of oxidative stress and inflammation.
Molecular Mechanisms of Cytokine Storm in Multiple Organ Failure: From Pathogenesis to Targeted Therapies
This article provides a comprehensive analysis of the pathophysiology linking cytokine storm (CS) to multiple organ failure (MODS), a life-threatening condition in sepsis, COVID-19, and immunotherapies.
NF-κB Signaling in Inflammatory Diseases: Mechanisms, Therapeutic Targeting, and Clinical Perspectives
This article provides a comprehensive analysis of the Nuclear Factor-kappa B (NF-κB) signaling pathway and its central role in the pathogenesis of inflammatory diseases.
Macrophage Polarization in Chronic Inflammation: Molecular Mechanisms, Therapeutic Targeting, and Clinical Implications
This article provides a comprehensive analysis of the mechanisms governing macrophage polarization and its pivotal role in chronic inflammatory diseases.
Systemic Inflammation Biomarkers in Disease Prognostication: A Comprehensive Analysis of NLR, PLR, and LMR Across Clinical Contexts
This comprehensive review synthesizes current evidence on neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR) as prognostic biomarkers across inflammatory diseases and cancer immunotherapy. Drawing from recent meta-analyses and clinical studies, we examine the foundational biology underlying these hematological indices, standardized methodological approaches for their application, strategies to address measurement variability, and comparative performance validation across diverse clinical contexts including inflammatory bowel disease, non-alcoholic fatty liver disease, gastric cancer, and melanoma. The analysis demonstrates that elevated NLR and PLR consistently correlate with poorer survival outcomes and increased disease activity, while higher LMR generally indicates improved prognosis. These readily accessible biomarkers offer significant potential for enhancing risk stratification, treatment monitoring, and clinical decision-making in both inflammatory conditions and oncology.
The Hidden Storm: How a Simple Blood Test Can Predict Heart Attack Recovery
Discover how the Inflammatory Prognostic Index (IPI) helps predict recovery outcomes for NSTEMI heart attack patients after stent procedures.
The Robotic Surgeon's Secret Weapon: A Blood Test That Measures Hidden Trauma
Discover how the Systemic Immune-Inflammatory Index (SII) is revolutionizing surgical assessment in robot-assisted pelvic fracture fixation by measuring hidden trauma through simple blood tests.
Targeting Innate Immune Memory: A New Paradigm for Gout Treatment
Explore how targeting innate immune memory through trained immunity represents a revolutionary approach to treating gout, moving beyond traditional urate-lowering therapies.
Beyond Seizure Control: How an Common Anti-Inflammatory Drug Could Revolutionize Epilepsy Treatment
Exploring how meloxicam, a common anti-inflammatory drug, shows promise in attenuating PTZ-induced seizures through neuroinflammation modulation.
The Hidden Journey of CAR-T Cells: Mapping Living Drugs in the Human Body
Explore the groundbreaking research on CAR-T cell spatio-temporal kinetics in blood and serous cavity effusions, revealing how living drugs navigate the human body.